Computerized nuclear morphometry in the diagnosis of thyroid lesions with predominant follicular pattern

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Computerized nuclear morphometry in the diagnosis of thyroid lesions with predominant follicular pattern

BACKGROUND Differential diagnosis of thyroid lesions with predominantly follicular pattern is one of the most common problems in thyroid pathology. Development of more objective and reproducible tools for diagnosis is needed. This work is aimed at studying the role of nuclear morphometry in differential diagnosis of different thyroid lesions having predominant follicular pattern. MATERIAL AND...

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Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma.

Distinguishing follicular variant of papillary carcinoma (FVPC) from follicular adenoma and follicular carcinoma can be difficult if nuclear features of papillary carcinoma are not well developed or only focally present. We assessed interobserver and intraobserver agreement among 6 thyroid experts by using 15 cases in which original pathologists suspected FVPC. There was unanimous expert agreem...

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[Contribution of nuclear texture analysis for the differential diagnosis of follicular lesions of the thyroid: comparison to immunohistochemical markers].

OBJECTIVE AND METHODS To investigate the utility of nuclear chromatin texture assessment in the differential diagnosis of follicular patterned lesions, by means of examining 76 samples previously submitted to the immunohistochemical protein analysis of HBME-1, CK-19 and galectina-3. RESULTS HBME-1 confirmed to be the most sensitive marker of malignancy. A series of morphometric, densitometric...

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Nuclear Features in the Diagnosis of Follicular Variant of Papillary Thyroid Carcinoma—The Diagnostic Dilemma

Aim: Follicular variant of papillary thyroid carcinoma [FVPC] as a diagnostic entity has been beset by many controversies. In this study, we describe the nuclear features essential for the diagnosis and analyze the difficulties that confront pathologists as it is important to avoid pitfalls because appropriate management protocol depends upon on an accurate diagnosis of this variant. Materials ...

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ژورنال

عنوان ژورنال: ecancermedicalscience

سال: 2010

ISSN: 1754-6605

DOI: 10.3332/ecancer.2009.146